|Year : 2020 | Volume
| Issue : 2 | Page : 72-79
Functional foods for mental health promotion
Soumam Dutta1, Sohini Roy2, Sanchari Roy3
1 Department of Home Science (Food and Nutrition Division), University of Calcutta, Calcutta, West Bengal, India
2 Department of Food and Nutrition, Women's College, Calcutta, West Bengal, India
3 Department of Psychiatry, Calcutta National Medical College and Hospital, Kolkata, West Bengal, India
|Date of Submission||09-Feb-2020|
|Date of Acceptance||12-Jun-2020|
|Date of Web Publication||15-Dec-2020|
Mr. Soumam Dutta
Department of Home Science (Food and Nutrition Division), University of Calcutta, 20E, Judges Court Road, Kolkata - 700 027, West Bengal
Source of Support: None, Conflict of Interest: None
Mental health problems and morbidities are increasing day by day. The etiology of mental health disorders is extremely complex and encompasses a range of genetic, dietary, emotional, and social as well as lifestyle factors. Finding adequate therapeutic and preventive strategies for mental health promotion is a great challenge. India is a country which is famous for its flora and fauna, many of which possess functional and medicinal properties. This article summarizes the mental health role of some selected functional foods of Indian origin, namely, brahmi (Bacopa monnieri), ashwagandha (Withania somnifera), turmeric (Curcuma longa), garlic (Allium sativum), and pumpkin seeds (Cucurbita maxima). Relevant article searches were conducted in PubMed, Google Scholar, and Google to identify the scientific articles highlighting the role of the functional foods on various mental health problems such as neurodegeneration, Alzheimer's disease, Parkinson's disease, depression, epilepsy, stress, and anxiety. The eligible articles were reviewed to gather information. These functional foods were found to be highly beneficial in treating and preventing mental health disorders mainly due to their antioxidant and anti-inflammatory properties as well as their ability to prevent mitochondrial dysfunction and degrade abnormal protein aggregates. These functional foods were also found to be effective in the improvement of the activities of various neurotransmitters such as acetylcholine and monoamines. These foods can be incorporated into the diet as well as can be used to develop drugs and nutraceuticals for treating various psychiatric problems.
Keywords: Antioxidant, functional food, mental health, neurodegeneration, protein aggregates
|How to cite this article:|
Dutta S, Roy S, Roy S. Functional foods for mental health promotion. J Mahatma Gandhi Inst Med Sci 2020;25:72-9
| Introduction|| |
A sound mind in a sound body is a social ideal. According to the World Health Organization, mental health has been defined as “a state of well-being, in which the individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully and can make a contribution to his or her community.” The all India prevalence of mental morbidity (lifetime), mental morbidity (current), intellectual disability, epilepsy, and suicidal risk are 13.9%, 10.5%, 0.6%, 0.29%, and 6.4%, respectively. It is estimated that in India, over 3.7 million people (aged over 60) have dementia, which is expected to be double by 2030. The etiology of mental health disorders is extremely complex and encompasses a range of genetic, dietary, emotional, social, and lifestyle factors. This article targets to focus on the mental health-promoting properties of some selected functional foods of Indian origin. The roles of brahmi saag, ashwagandha, turmeric, garlic and pumpkin seeds have been discussed.
The aim of this study is to explore the existing scientific literature on some selected functional foods of Indian origin, which have an effective role in mental health promotion.
| Methodology|| |
Functional foods that have been studied extensively in the scientific literature for their mental health-promoting properties were identified through literature search. Initially, eight items were identified, namely brahmi, ashwagandha, turmeric, shankhpushpi, mandukaparni, guggulu, garlic and pumpkin seeds.,,, Out of these those which are easily available and commonly used at the household level were selected for this review, namely brahmi, ashwagandha, turmeric, garlic, and pumpkin seeds . The searches were performed in PubMed, Google scholar, and Google. Search items like “functional food,” “mental health,” “neuroprotection,” “neurodegeneration,” “neuroinflammation,” “oxidative stress,” “antioxidant” were used. Relevant research and review articles were identified for this narrative review.
Mental health-promoting effects of some selected functional foods
“Brahmi Saag” (Bacopa monnieri)
Brahmi is a popular creeping herb from the plant family Scrophulariaceae found in India. It is classified in Ayurvedic texts as “medhya-rasayana” (memory enhancer and rejuvenator) and “aindra-rasayana” (increasing longevity). In “Charaka Samhita,” it is recommended for the management of various conditions such as anxiety, lack of concentration, and cognitive impairment. It can be taken in various forms such as ghrita (medicated ghee), fresh juice, paste, milk decoction, tea, powder, and pill. It is found to possess nootropic, anti-convulsant, analgesic, anti-depressant, anxiolytic, anti-inflammatory, anti-oxidant, and adaptogenic properties. The dammarane types of triterpenoid saponins, also known as Bacosides are present in Bacopa monnieri (BM) extract as the main nootropic agents. The Bacoside A is most extensively studied and has four types: Bacoside A3, Bacopaside X, Bacopaside II, and Bacopasaponin C. These Bacosides are present as aglycone units with jujubogenin or pseudojujubogenin. They regulate translation of mRNA and expression of various neuroreceptors namely α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, N-methyl-D-aspartate (NMDA) receptor, and gamma-aminobutyric acid receptor in the brain. BM mainly acts by anti-oxidant neuroprotection, inhibition of acetylcholinesterase and/or activation of choline acetyltransferase, reduction of β-amyloid, increased cerebral blood flow, and modulation of neurotransmitter acetylcholine, serotonin, and dopamine.
In vitro studies
BM extracts significantly inhibit the release of pro-inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin [IL]-6) from the microglial cells and thus may be beneficial in the treatment of central nervous system inflammation. A standardized extract of BM is found to inhibit three enzymes, namely poly (ADP-ribose) polymerase (PARP), catechol-o-methyl transferase, prolyl endopeptidase and act as an antagonist of serotonin 6 and 2a receptors leading to memory enhancement.
In vivo animal studies
Supplementation with BM extract (50 mg/kg/day for 15 days) is found to improve oxidative stress, inflammatory markers and reduce amyloid beta plaque formation in colchicine induced dementia in male Wistar rats. BM increases GABAergic neurones in the brain of rat models of schizophrenia and enhances cognitive performance. In epileptic rats treatment with BM extract improves alterations in 5-hydroxytryptamine (5-HT2 C) receptor, NMDA receptors, metabotropic glutamate receptor 5, glutamate and aspartate transporter, inositol triphosphate (IP3) content and thus shows anti-epileptic properties. BM extract also reduces depressive like behavior in rat models of depression induced by chronic unpredictable stress.
Oral administration of a standardized extract of BM at a dosage of 150 mg twice daily for 6 weeks has been shown to improve cognition and performance in certain neuropsychological tests namely digit span backwards and logical memory test in the intervention group among medical students. Standardized extract of BM is also found to be effective in reducing the symptoms of attention deficit hyperactivity disorder and is well-tolerated by children. Although another study with healthy adults (35–60 years) found that BM extract at a dosage of 450 mg/day for 12 weeks leads to a lower anxiety level in the intervention group but does not improve cognitive status.
Ashwagandha (Withania somnifera)
Ashwagandha (Withania somnifera [WS]) belongs to the plant family of Solanaceae. In Ayurveda it is classified as a “rasayana” (rejuvenator). In “Charaka Samhita,” “Susruta Samhita” and “Nighantus” it is recommended for various conditions such as “vataroga,” “kustha” (leprosy), “pachan” (digestion), “jwara” (fever), strength and is praised for its anti-inflammatory, immunomodulatory properties and its influence on the endocrine, nervous, cardiopulmonary, and reproductive systems. It is usually consumed in the form of churna or powder with honey, ghee or milk. It possesses adaptogenic or antistress, antioxidant, anxiolytic, anti-neuroinflammatory, and GABA mimetic effects. The ashwagandha leaf extract is found to reverse the pathology of Alzheimer's and Parkinson's disease, enhance memory and protect against environmental neurotoxins.
In vitro studies
The neuroprotective properties of WS extracts and their bioactive compounds were evaluated by using cultured glioblastoma and neuroblastoma cells. It was observed that the extract and one purified component named withanone at a low dose protected the glial cells and the neuronal cells from oxidative damage and glutamate insult as well as induced their ability to differentiate. Alkaloids and steroidal lactones are found to be present in the methanol: chloroform (3:1) extract of dried ashwagandha roots. Withanolide A is the prominent one and is found to be neuroprotective against beta-amyloid-induced cytotoxicity.
In-vivo animal studies
WS extract has been found to ameliorate the level of Bisphenol A (major endocrine disruptor and xenobiotic) intoxicated oxidative stress and thus treating cognitive functions. Water extract of ashwagandha leaf containing triethylene glycol as a major component has been shown to induce non-rapid eye movement sleep significantly with a slight alteration in rapid eye movement sleep in experimental rat models. It indicates that WS can be used potentially for insomnia therapy. An active metabolite of Withanoside IV called sominone was found to phosphorylate RET (“rearranged during transfection”), a receptor for glial cell-derived neurotrophic factor. Thus it increased the morphological plasticity of neurones and enhanced memory in normal mice.
WS root extract at a dosage of 300 mg twice daily for 8 weeks is found to be effective in mild cognitive impairment (MCI) and also in the improvement of attention, executive function, and information processing speed in adults with MCI. WS extract supplementation at a dosage of 120 mg/day along with selective serotonin reuptake inhibitors (SSRI) for 6 weeks is beneficial and safe in the treatment of obsessive compulsion disorder. Similarly, WS extract at a dosage of 1 g/day for 6 weeks along with SSRI is found to be effective in the treatment of generalized anxiety disorder. WS may also be beneficial for the improvement of cognitive dysfunction associated with bipolar disorder.
Turmeric (Curcuma longa)
Turmeric is a very popular native South Asian spice which belongs to the plant family Zingiberaceae. In “Charaka Samhita” and “Susruta Samhita” it is recommended for curing skin diseases (“kustaghna”), antidote to poisoning (“visaghna”), anti-obesity (“lekhaniya”) and anti-parasitic (“krimighna”) effects. “sayana” mentioned turmeric as a nootropic agent (“medhya”) when consumed with honey and ghee. It can also be consumed with milk, as herbal tea or added to food while cooking. Turmeric is popularly known for its anti-inflammatory and antioxidant properties. A well-recognized compound present in turmeric is curcumin (diferuloylmethane) which is found to possess potent neuro-protective properties. Other compounds like phenolic and flavonoid antioxidants, curcuminoids, and some other functional monosaccharides have also been characterized. Curcumin may be highly beneficial in the treatment of various brain-related disorders such as Alzheimer's disease, Parkinson's disease, autism, multiple sclerosis, and aging-associated neurodysfunctions.
In vitro studies
Curcumin is found to inhibit beta-amyloid fibril formation from amyloid-beta peptide as well as destabilize preformed beta-amyloid fibrils in a dose-dependent manner. Macrophages of Alzheimer's patients when treated with curcuminoids have shown significant increase in the uptake of beta-amyloid fractions. Such immunomodulatory effect of curcuminoids helps in the clearance of beta-amyloid plaques.
In vivo animal studies
Curcumin is found to enhance postsynaptic electrical reactivity and viability of cells in intact neural circuits with antidepressant-like effects by up regulating brain derived neurotrophic factor (BDNF) and reducing inflammatory factors in the brain of chronically stressed rats. Tetrahydrocurcumin, a major metabolite of curcumin, increases the activities of catalase, superoxide dismutase, glutathione peroxidase, reduced glutathione and glutathione-S-transferase in brain tissue of diabetic rats and prevents lipid peroxidation. Curcumin decreases polyglutamine-induced cytotoxicity, neuronal dysfunction and neurodegeneration in the Drosophila model of Huntington's Disease. It also reduces seizures and hippocampal neuronal loss in rat model of temporal lobe epilepsy. Curcumin prevents cognitive-deficits associated with alcohol consumption in a dose-dependent manner. It increases the production of docosahexaenoic acid (DHA) from its precursor compound, alpha-linolenic acid (ALA) and also increases the levels of enzymes which are found to be involved in the synthesis of DHA such as elongase 2 and fatty acid destaurase 2 (FADS2) in both liver and brain tissues of rats. Elevation of brain DHA levels may be possible pathway through which curcumin results in cognitive improvement.
Curcumin supplementation (360 mg/day) for 8 weeks may improve BDNF levels in patients with schizophrenia. Genetic expression of BDNF may be increased via phosphorylated cAMP response element binding protein by Curcumin leading to such effect. Supplementation of curcumin is also found to increase brain-derived neurotrophic factor (BDNF) levels in women having premenstrual syndrome (PMS) and decrease the symptoms of PMS. Curcumin at a dose of 1000 mg/day for 6 weeks is found to decrease depressive symptoms, pro-inflammatory cytokines (IL-1β and TNF-α) and salivary cortisol and increase the efficiency of anti-depressant treatment in adult male patients having major depressive disorder.
Garlic (Allium sativum)
Garlic is a medicinal herb which is used in different traditional systems of medicine. It belongs to the plant family Amaryllidaceae. In “Kashyapa Samhita” it is mentioned as a “Rasayana” (rejuvenator). According to “Kashyapa” it is an appetizer, aphrodisiac, clarifier of memory and intellect and is recommended for various conditions like “vataroga,” cough, skin diseases, menstrual disorders, seminal disorders, increasing longevity etc. It can be eaten in fresh form or added to food preparations. Garlic has been used extensively in the prevention and treatment of different cardiovascular diseases. Cerebrovascular disorders and metabolic syndrome are frequently associated with the development of dementia, Alzheimer's disease, cognitive impairment and other mental health morbidities. The well-known risk factors involved in the development of cardiovascular as well as cerebrovascular diseases are high blood cholesterol, high homocysteine, hyperglycemia, inflammation, hyper tension, atherosclerosis, and oxidative stress. High cholesterol level is associated with cognitive dysfunction, increased neuroinflammation, and amyloid precursor protein processing. Garlic is found to possess hypotensive, hypoglycemic, hypocholesterolemic, hypolipidemic, anti-thrombotic, and anti-atherosclerotic properties. Thus, it also improves cerebrovascular health and may show neuroprotective properties. The bioactive principles present in garlic are the organosulfur compounds (OSCs), especially allicin (diallyl thiosulfinate) which is produced from alliin by an enzyme alliinase when crushed.
In vitro studies
Raw garlic is found to possess potent anti-neuroinflammatory properties and this is due to the alliin derived OSCs (like allicin, diallyl trisulfide, diallyl disulfide). These compounds, especially diallyl trisulfide, and diallyl disulfide, decrease the production of TNF-α, lipopolysaccharide (LPS) induced nitric oxide, monocyte chemoattractant protein-1 and IL-1β in LPS stimulated microglial cells. Similarly, a sulfur containing compound named thiacremonone decreases LPS induced activation of glial cell and inflammatory mediators, which are involved in amyloidogenesis. These compounds inhibit the activation of nuclear factor (NF)-κB pathway and thereby reduce inflammation. Aged garlic extract and S-allyl-cysteine also have neuroprotective properties and reduce amyloid-beta peptide-induced apoptosis in pheochromocytoma (PC12) cells possibly by improving the endogenous antioxidant defense mechanisms.
In vivo animal studies
Raw garlic and low temperature aged garlic administration (500 mg/kg) to stressed mice were found to reverse the levels of stress related hormones (e.g., cortisol, corticosterone, adrenocorticotrophic hormone, corticotropin releasing factor) and changes in the neurotransmitters of the brain (e.g., epinephrine, nor-epinephrine, dopamine, serotonin). Garlic improves learning and memory impairment associated with lead exposure in juvenile rats by preventing oxidative damage and decreasing lead content. Garlic also reduces anxiety and depression-related behaviors in diabetic rats. In depression, the levels of monoamine oxidase enzyme (MAO) in the brain are found to be increased, which in turn reduce the levels of monoamines, namely nor-epinephrine, serotonin and dopamine. Garlic extract reduces the levels of monoamine oxidases (MAO-A and MAO-B) in the brain, thereby showing anti-depressant like activity.
Clinical studies have shown mixed results regarding the effect of garlic on lipid profile and other markers of metabolic syndrome which are associated with mental health disorders. Supplementation of aged black garlic (6 g/day) for 12 weeks is found to increase high density lipoprotein (HDL) levels and decrease apolipoprotein B levels in patients having mild hypercholesterolemia. Some studies have found no significant effect of garlic therapy on lipid profiles and psychopathologic parameters. Although a recent meta-analysis of clinical studies has confirmed the beneficial effect of garlic on reducing total cholesterol, low-density lipoprotein, triglyceride, fasting blood sugar, glycated hemoglobin (HbA1c) levels and increasing HDL levels. Such improvements may have highly beneficial effects on mental health.
Pumpkin seeds (Cucurbita maxima)
Pumpkin seeds are usually considered as agro-wastes and are discarded in spite of their high nutritive value and medicinal properties. Pumpkin belongs to the plant family Cucurbitaceae. The plant is widely grown in India and is conventionally used in Ayurveda. Pumpkin seeds are classified under the nuts and seeds group. It is 'tridoshic' and can be recommended in the “ahara” (diet) of “kapha Prakriti,” “vata prakriti” and “pitta prakriti” individuals based on the principle of “viruddha guna” (selection of food items having qualities which are opposite to the dominant qualities of the individuals). They can be consumed in the fresh form, roasted form or can be added to food preparations. Pumpkin seeds contain high amounts of L-tryptophan (576 mg/100 g) and choline (63 mg/100 g). L-tryptophan is widely used in the management of various medical conditions such as depression, anxiety, insomnia, hyperactivity, mood disorders, pain, and eating disorders. Tryptophan can be converted to serotonin in the body which in turn may regulate various neuropsychological processes. Choline is known to be the precursor for the formation of the neurotransmitter acetylcholine in cholinergic synapses that provide stimulatory transmission in the nervous system. Choline also helps in brain development.
In vitro studies
Pumpkin seed extract scavenges 2,2-diphenyl-1-picrylhydrazyl free radicals and inhibits lipoxygenase enzyme due to its phenolic content.
In vivo animal studies
Oral administration of pumpkin seed oil (100 mg/kg and 200 mg/kg for 5 days) is found to exert anti-amnesic effects against scopolamine-induced amnesia in adult male Wistar rats. It inhibits acetylcholine esterase, decreases TNF-α expression in the hippocampus and increases glutathione levels in the brain. Pumpkin seeds are also found to reduce depression and improve memory of experimental rats.
Daily supplementation of 40 g of pumpkin seed (nutrient balls) to school-going children (6–8 years) and bread prepared from germinated pumpkin seeds (100 g bread containing 1 g of tryptophan) to moderate depressive adults (20–50 years) for one month were found to improve memory function and symptoms of depression, respectively.
| Discussion|| |
Neurodegeneration and neurodegenerative diseases are becoming more prevalent day by day. Brahmi, ashwagandha, turmeric and garlic are found to be effective in the reversal of such diseases. [Table 1] summarizes their effect on the etiological factors of the neurodegenerative diseases. Anti-acetylcholinesterase activity is also shown by brahmi, ashwagandha, and turmeric which may improve cholinergic neurotransmission in the brain and may compensate for the decreasing amount of functioning brain cells associated with various neurodegenerative diseases. Monoamine oxidase inhibitory properties are shown by garlic, brahmi and turmeric. Pumpkin seeds show their anti-depressant properties mainly due to their L-tryptophan content and antioxidant effects. [Table 2] summarizes the dosage ranges and compositions of brahmi, ashwagandha, and turmeric for their neuroactive properties suitable for human subjects. Crushed garlic at a dose of 100 mg/kg body weight improves the components of metabolic syndrome. Pumpkin seeds have shown positive effects on depressive symptoms and memory at a dosage of 35–40 g/day in human subjects., These dosage ranges can be safely used in humans.
|Table 1: Effect of Bacopa, Withania, Curcuma and Allium on factors associated with Neurodegeneration|
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|Table 2: Dosage ranges for neuroactive properties of Bacopa, Withania and Curcuma|
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These functional foods can either be incorporated in the daily diet (raw or cooked) or be used in the development of newer drugs. Different cooking methods also alter the bioavailability of certain active compounds. Brahmi and ashwagandha are not generally cooked. The total antioxidant capacity of cooked curcuminoids is decreased slightly depending on the cooking method. Boiled curcuminoids are stronger than the roasted form and the fried form is the weakest. Cooking decreases the allicin content of garlic. Crushing garlic prior to cooking is found to minimize such losses. Antioxidant content of pumpkin seeds is also decreased by cooking. The losses of active compounds can be compensated by increased consumption.
| Conclusion|| |
Mental health promotion is the need of the current era. Using functional foods can be a well acceptable way to promote mental health, although further research is needed in areas which are not evaluated so far. Although further research works are required in the unevaluated areas. Moreover, knowledge regarding the benefits of these functional foods should be disseminated to the public.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
WHO. Promoting Mental Health. Concepts, Emerging Evidence, Practice. Summary Report. Department of Mental Health and Substance Abuse in collaboration with the Victorian Health Promotion Foundation and the University of Melbourne. Geneva: World Health Organization; 2004.
Gururaj G, Varghese M, Benegal V, Rao GN, Pathak K, Singh LK, et al
. National Mental Health Survey of India, 2015-16: Prevalence, Patterns and Outcomes. NIMHANS Publication No. 129. Bengaluru: National Institute of Mental Health and Neuro Sciences; 2016.
Shaji KS, Jotheeswaran AT, Girish N, Bharath S, Dias A, Pattabiraman M, et al
. The dementia India report: Prevalence, impact, costs and services for dementia: Executive summary. Alzheimer's & Related Disorders Society of India. New Delhi; ARDSI; 2010.
Farooqui AA, Farooqui T, Madan A, Ong JH, Ong WY. Ayurvedic medicine for the treatment of dementia: Mechanistic aspects. Evid Based Complement Alternat Med 2018;2018:2481076.
Nishteswar K, Joshi H, Karra RD. Role of indigenous herbs in the management of Alzheimer's disease. Anc Sci Life 2014;34:3-7.
Chauhan NB. Multiplicity of garlic health effects Alzheimer's disease. J Nutr Health Aging 2005;9:421-32.
Roy S, Datta S. A comprehensive review of the versatile pumpkin seeds (Cucurbita maxima
) as a valuable natural medicine. Int J Curr Res 2015;7:19355-61.
Russo A, Borrelli F. Bacopa monniera
, a reputed nootropic plant: An overview. Phytomedicine 2005;12:305-17.
Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri
. Rejuvenation Res 2013;16:313-26.
Sekhar VC, Viswanathan G, Baby S. Insights into the molecular aspects of neuroprotective bacoside A and bacopaside I. Curr Neuropharmacol 2019;17:438-46.
Nemetchek MD, Stierle AA, Stierle DB, Lurie DI. The ayurvedic plant Bacopa monnieri
inhibits inflammatory pathways in the brain. J Ethnopharmacol 2017;197:92-100.
Dethe S, Deepak M, Agarwal A. Elucidation of molecular mechanism (s) of cognition enhancing activity of bacomind®: A standardized extract of Bacopa monnieri
. Pharmacogn Mag 2016;12:S482-7.
Saini N, Singh D, Sandhir R. Bacopa monnieri
prevents colchicine-induced dementia by anti-inflammatory action. Metab Brain Dis 2019;34:505-18.
Piyabhan P, Tingpej P, Duansak N. Effect of pre- and post-treatment with Bacopa monnieri
) on phencyclidine-induced disruptions in object recognition memory and cerebral calbindin, parvalbumin, and calretinin immunoreactivity in rats. Neuropsychiatr Dis Treat 2019;15:1103-17.
Krishnakumar A, Anju TR, Abraham PM, Paulose CS. Alteration in 5-HT2
C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: Restorative role of Bacopa monnieri
. Neurochem Res 2015;40:216-25.
Kumar S, Mondal AC. Neuroprotective, neurotrophic and anti-oxidative role of Bacopa monnieri
on CUS induced model of depression in rat. Neurochem Res 2016;41:3083-94.
Kumar N, Abichandani LG, Thawani V, Gharpure KJ, Naidu MU, Venkat Ramana G. Efficacy of standardized extract of Bacopa monnieri
(Bacognize®) on cognitive functions of medical students: A six-week, randomized placebo-controlled trial. Evid Based Complement Alternat Med 2016;2016:4103423.
Dave UP, Dingankar SR, Saxena VS, Joseph JA, Bethapudi B, Agarwal A, et al
. An open-label study to elucidate the effects of standardized Bacopa monnieri
extract in the management of symptoms of attention-deficit hyperactivity disorder in children. Adv Mind Body Med 2014;28:10-5.
Sathyanarayanan V, Thomas T, Einöther SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi
for the better? New findings challenging cognition and anti-anxiety effects of Brahmi
) in healthy adults. Psychopharmacology (Berl) 2013;227:299-306.
Chaudhary SP. An ayurvedic review of ashwagandha
from samhita and nighantus. WJPR 2015;4:2736-45.
Wadhwa R, Konar A, Kaul SC. Nootropic potential of ashwagandha
leaves: Beyond traditional root extracts. Neurochem Int 2016;95:109-18.
Shah N, Singh R, Sarangi U, Saxena N, Chaudhary A, Kaur G, et al
. Combination of ashwagandha
leaf extracts protect brain-derived cells against oxidative stress and induce differentiation. PLoS One 2015;10:e0120554.
Venkata Kurapati KR, Rao Atluri VS, Samikkannu T, Nair MP. ashwagandha
) reverses β-Amyloid1-42 induced toxicity in human neuronal cells: Implications in HIV-associated neurocognitive disorders (HAND). PLoS One 2013;8:e77624.
Birla H, Keswani C, Raj SN, Singh SS, Zahra W, Dilnashin H, et al
. Neuroprotective effects of Withania somnifera
in BPA induced-cognitive dysfunction and oxidative stress in mice. Behav Brain Funct 2019;15:9.
Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y. Triethylene glycol, an active component of ashwagandha
) leaves, is responsible for sleep induction. PLoS One 2017;12:e0172508.
Tohda C, Joyashiki E. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br J Pharmacol 2009;157:1427-40.
Choudhary D, Bhattacharyya S, Bose S. Efficacy and safety of ashwagandha
(L.) Dunal) root extract in improving memory and cognitive functions. J Diet Suppl 2017;14:599-612.
Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour B, Mohammadpour AH, et al
. Evaluation of the efficacy of Withania somnifera
) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial. Complement Ther Med 2016;27:25-9.
Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Curr Clin Pharmacol 2020;10.2174/1574884715666200413120413. doi:10.2174/1574884715666200413120413. [Published online ahead of print, 2020 Apr 13].
Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera
for cognitive dysfunction in bipolar disorder. J Clin Psychiatry 2013;74:1076-83.
Durga Prasad VV, Prakash LH, Harini A. A comprehensive study on Haridra (Curcuma longa
linn.). WJPMR 2016;2:54-6.
Ghiamati Yazdi F, Soleimanian-Zad S, van den Worm E, Folkerts G. Turmeric extract: Potential use as a prebiotic and anti-inflammatory compound? Plant Foods Hum Nutr 2019;74:293-9.
Bhat A, Mahalakshmi AM, Ray B, Tuladhar S, Hediyal TA, Manthiannem E, et al
. Benefits of curcumin in brain disorders. Biofactors 2019;45:666-89.
Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
. J Neurosci Res 2004;75:742-50.
Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, et al
. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis 2006;10:1-7.
Choi GY, Kim HB, Hwang ES, Lee S, Km MJ, Choi JY, et al
. Curcumin alters neural plasticity and viability of intact hippocampal circuits and attenuates behavioral despair and COX-2 expression in chronically stressed rats. Mediators Inflamm 2017;2017:6280925.
Pari L, Murugan P. Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats. J Med Food 2007;10:323-9.
Chongtham A, Agrawal N. Curcumin modulates cell death and is protective in Huntington's disease model. Sci Rep 2016;6:18736.
Kiasalari Z, Roghani M, Khalili M, Rahmati B, Baluchnejadmojarad T. Antiepileptogenic effect of curcumin on kinate-induced model of temporal lobe epilepsy. Pharm Biol 2013;51:1572-8.
Tiwari V, Chopra K. Protective effect of curcumin against chronic alcohol-induce cognitive deficits and neuroinflammation in the adult rat brain. Neuroscience 2013;244:147-58.
Wu A, Noble EE, Tyagi E, Ying Z, Zhuang Y, Gomez-Pinilla F. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Biochim Biophys Acta 2015;1852:951-61.
Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR. The effects of curcumin on brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study. Schizophr Res 2018;195:572-3.
Fanaei H, Khayat S, Kasaeian A, Javadimehr M. Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial. Neuropeptides 2016;56:25-31.
Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL. Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol 2015;35:406-10.
Arora P, Acharya SK. Lashuna (Garlic): A wonder drug in childhood disorders – Review. IAMJ 2018;2:1158-64.
Khalid R, Gordon ML. Garlic and cardiovascular disease: A critical review. J Nutr 2006;136:736S-40S.
Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S. Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci 2013;16:1031-48.
Ho SC, Su MS. Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds. Molecules 2014;19:17697-714.
Lin GH, Lee YJ, Choi DY, Han SB, Jung JK, Hwang BY, et al
. Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro
and in vivo
models. J Alzheimers Dis 2012;29:659-76.
Peng Q, Buz'Zard AR, Lau BH. Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro
. Med Sci Monit 2002;8:BR328-37.
Hwang KA, Hwang YJ, Hwang IG, Song J, Jun Kim Y. Low temperature-aged garlic extract suppresses psychological stress by modulation of stress hormones and oxidative stress response in brain. J Chin Med Assoc 2019;82:191-5.
Ghasemi S, Hosseini M, Feizpour A, Alipour F, Sadeghi A, Vafaee F, et al
. Beneficial effects of garlic on learning and memory deficits and brain tissue damages induced by lead exposure during juvenile rat growth is comparable to the effect of ascorbic acid. Drug Chem Toxicol 2017;40:206-14.
Rahmani G, Farajdokht F, Mohaddes G, Babri S, Ebrahimi V, Ebrahimi H. Garlic (Allium sativum
) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats. Arch Physiol Biochem 2020;126:95-100.
Dhingra D, Kumar V. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J Pharmacol 2008;40:175-9.
] [Full text]
Jung ES, Park SH, Choi EK, Ryu BH, Park BH, Kim DS, et al
. Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: A randomized controlled trial. Nutrition 2014;30:1034-9.
Peleg A, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia. Isr Med Assoc J 2003;5:637-40.
Shabani E, Sayemiri K, Mohammadpour M. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Prim Care Diabetes 2019;13:28-42.
Ramakrishna BR, Kishore KR, Vasudev V, Nagenra HR. Healthy life-style prescriptions for different personality types (Tridosha prakriti). J Ayurveda Hol Med 2014;2:30-6.
U.S. Department of Agriculture, Agricultural Research Service. Food Data Central; 2019. Available from: http://fdc.nal.usda.gov
. [Last accessed on 2019 May 19].
Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic metabolic functions, behavioral research and therapeutic indications. Int J Tryptophan Res 2009;2:45-60.
Zeisel SH. Nutritional importance of choline for brain development. J Am Coll Nutr 2004;23:621S-6S.
Xanthopoulou MN, Nomikos T, Fragopoulou E, Antonopoulou S. Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Res Int 2009;42:641-6.
Jawaid T, Shakya AK, Siddiqui HH, Kamal M. Evaluation of Cucurbita maxima
extract against scopolamine-induced amnesia in rats: Implication of tumour necrosis factor alpha. Z Naturforsch C J Biosci 2014;69:407-17.
George S, Nazni P. Antidepressive activity of processed pumpkin (Cucurbita maxima
) seeds on rats. Int J Pharm Med Biol Sci 2012;1:225-31.
Shemi G. Effective Utilization of Processing Techniques on Nutritional and Pharmacological Activities of Pumpkin Seeds. Thesis. Periyar University, Periyar, Shodhganga; 2012. Available from: http://hdl. handle.net/10603/40393
. [Last accessed on 2019 May 19].
Rani A, Prasad S. A special extract of Bacopa monnieri
(CDRI-08)-restored memory in CoCl2-hypoxia mimetic mice is associated with upregulation of Fmr-1 gene expression in hippocampus. Evid Based Complement Alternat Med 2015;2015:347978.
Panossian A, Seo EJ, Efferth T. Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signalling pathways in isolated brain cells. Phytomedicine 2019;60:152881.
Wu J, Li Q, Wang X, Yu S, Li L, Wu X, et al
. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS One 2013; 8:e59843.
Huang YJ, Lu KH, Lin YE, Panyod S, Wu HY, Chang WT, et al
. Garlic essential oil mediates acute and chronic mild stress-induced depression in rats via modulation of monoaminergic neurotransmission and brain-derived neurotrophic factor levels. Food Funct 2019;10:8094-105.
Kapoor R, Srivastava S, Kakkar P. Bacopa monnieri
modulates antioxidant responses in brain and kidney of diabetic rats. Environ Toxicol Pharmacol 2009;27:62-9.
Durg S, Dhade SB, Vandal R, Shivakumar BS, Charan CS. Withania somnifera
) in neurobehavioural disorders induce by brain oxidative stress in rodents: A systematic review and meta-analysis. J Pharm Pharmacol 2015;67:879-99.
Dairam A, Foqel R, Daya S, Limson JL. Antioxidant and iron-binding properties of curcumin, capsaicin, and S
-allylcysteine reduce oxidative stress in rat brain homogenate. J Agric Food Chem 2008;56:3350-6.
Shinomol GK, Bharath MM, Muralidhara M. Pretreatment with Bacopa monnieri
extract offsets 3-nitropropionic acid induced mitochondrial oxidative stress and dysfunctions in the striatum of prepubertal mouse brain. Can J Physiol Pharmacol 2012;90:595-606.
Kumar P, Kumar A. Possible neuroprotective effect of Withania somnifera
root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease. J Med Food 2009;12:591-600.
Eckert GP, Schiborr C, Haql S, Abdel-Kader R, Müller WE, Rimbach G, et al
. Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int 2013;62:595-602.
Atif F, Yousuf S, Agrawal SK. S-allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus. Brain Res 2009;1265:128-37.
Singh M, Murthy V, Ramassamy C. Standardized extracts of Bacopa monniera
protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways. Toxicol Sci 2012;125:219-32.
Widodo N, Shah N, Priyandoko D, Ishii T, Kaul SC, Wadhwa R. Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha
leaves. J Gerontol 2009;64A: 1031-8.
Ali RE, Rattan SI. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann N Y Acad Sci 2006;1067:394-9.
Holcomb LA, Dhanasekaran M, Hitt AR, Young KA, Riggs M, Manyam BV. Bacopa monniera
extract reduces amyloid levels in PSAPP mice. J Alzheimers Dis 2006;9:243-51.
Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, et al
. Withania somnifera
reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc Natl Acad Sci U S A 2012;109:3510-5.
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al
. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
. J Biol Chem 2004;280:5892-901.
Gupta VB, Indi SS, Rao KS. Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: Relevance to Alzheimer's disease. Phytother Res 2009;23:111-5.
Ahirwar S, Tembhre M, Gour S, Nameo A. Anticholinesterase efficacy of Bacopa monnieri
against the brain regions of rat – A novel approach to therapy for Alzheimer's disease. Asian J Exp Sci 2012;26:65-70.
Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, et al
. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. J Ethnopharmacol 2007;109:359-63.
Kalaycıoğlu Z, Gazioğlu I, Erim FB. Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa
L. Nat Prod Res 2017;31:2914-7.
Singh R, Ramakrishna R, Bhateria M, Bhatta RS.In vitro
evaluation of Bacopa monnieri
extract and individual constituents on human recombinant monoamine oxidase enzymes. Phytother Res 2014;28:1419-22.
Kulkarni SK, Bhutani MK, Bishnoi M. Antidepressant activity of curcumin: Involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008;201:435-42.
Raghav S, Singh H, Dalal PK, Srivastava JS, Asthana OP. Randomized controlled trial of standardized Bacopa monniera
extract in age-associated memory impairment. Indian J Psychiatry 2006;48:238-42.
] [Full text]
Downey LA, Kean J, Nemeh F, Lau A, Poll A, Gregory R, et al
. An acute, double-blind, placebo-controlled crossover study of 320mg and 640mg doses of a special extract of Bacopa monnieri
(CDRI 08) on sustained cognitive performance. Phtother Res 2013;27:1407-13.
Auddy B, Hazra J, MItra A, Abedon B, Ghosal S. A standardized Withania somnifera
extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. J Am Neutaceut Assoc 2008;11:50-6.
Khyati S, Anup T. A randomized double blind placebo controlled study of ashwagandha
on generelized anxiety disorder. Int Ayurvedic Med J 2013;1:1-7.
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, et al
. Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatry 2018;26:266-77.
Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, et al
. Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther 2012;4:43.
Choudhary PR, Jani RD, Sharma MS. Effect of raw crushed garlic (Allium sativum
L.) on components of metabolic syndrome. J Diet Suppl 2018;15:499-506.
Sun JL, Ji HF, Shen L. Impact of cooking on the antioxidant activity of spice turmeric. Food Nutr Res 2019;63:10.29219/fnr.v63.3451. Published 2019 May 31. doi:10.29219/fnr.v63.3451.
Cavagnaro PF, Camargo A, Galmarini CR, Simon PW. Effect of cooking on garlic (Allium sativum
L.) antiplatelet activity and thiosulfinates content. J Agric Food Chem 2007; 55:1280-8.
Olfati JA, Alaghemand S, Hamidoghli Y, Ghasemnezhad M. Pollination and cooking on antioxidant capacity in pumpkin pulp and seed. Int J Vegetable Sci 2015;21:397-401.
[Table 1], [Table 2]