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| NOBEL PRIZES |
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| Year : 2014 | Volume
: 19
| Issue : 1 | Page : 71 |
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The nobel prize in physiology or medicine 2013
| Date of Web Publication | 1-Feb-2014 |
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 Source of Support: None, Conflict of Interest: None  | Check |
How to cite this article:
. The nobel prize in physiology or medicine 2013. J Mahatma Gandhi Inst Med Sci 2014;19:71 |
Our body is made up of billions of cells. Each cell is a factory by itself producing number of molecules such as hormones, enzymes, neurotransmitters, and cytokines, and so on. To maintain proper functions of the systems, there is need to deliver right material in the right place at right time. The three scientists working on different lines discovered the precise control of transport system and delivery of this cellular cargo. Three sets of genes have been identified that control cells' transport system (Schekman). The proteins complexes discovered by Rothman are responsible for delivering the molecular posts at right place. Sudhof demonstrated how the nerve cells communicate with each other with precision timing. The shuttling work of molecules between the organelles of the cells or cells is carried out by tiny vesicles. They may fuse with the cell membrane and deliver the cargo. Any disturbance in this delivery system may have deleterious effect causing diabetes, neurological diseases, or immunological disorders.
James E Rothman received his Ph D in 1976 from Harvard University. Presently, he is working as Professor and Chairman in the Department of Cell Biology, Yale University in New Haven, Connecticut, USA He won 2002 Lasker award for basic medical research.
Randy Schekman studied at University of California, Los Angeles and Stanford University, receiving his Ph D in 1974 under Noble laureate Arthur Kornberg (Nobel Prize, 1959). Presently, he is Professor in the Department of Molecular and Cell Biology in the University of California at Berkeley. Recently, he was elected as a foreign member of Royal Society. He is also editor of an online Journal eLife.
Thomas Sudhof who is presently working as Professor of Molecular and Cellular physiology at Stanford University studied at Georg-August-Universität in Göttingen, where he received an MD in 1982 and a Doctorate in neurochemistry the same year. In 1983, he worked as a post doctoral fellow with Michael Brown and Joseph Goldstein (who shared the 1985 Nobel Prize in Physiology or Medicine at University of Texas. He is also recipient of both the Lasker award and the Kavli prize.
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