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Year : 2017  |  Volume : 22  |  Issue : 1  |  Page : 4-7

Role of atherosclerosis in pathogenesis of renal stone disease: Do all roads lead to Rome?

1 Department of Urology, Yashoda Hospitals, Hyderabad, Telangana, India
2 Department of Urology, Max Hospital Patparganj, New Delhi, India

Correspondence Address:
Yogendra Singh Gaharwar
Department of Urology, Yashoda Hospital, Malakpet, Hyderabad - 500 036, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-9903.202014

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Urolithiasis is as old as human civilization. Ancient Egyptian mummies and Indian Ayurvedic descriptions are testimony to this fact. Despite such an old association with humanity pathogenesis of renal stone disease remains far from fully understood. Randall's plaques were believed to be as initiating lesions for calcium oxalate stone since Randall's original description in 1937. However, the origin of Randall's plaque is not fully understood. Till recently, it was thought that excursion of calcium oxalate crystals into basolateral membrane of tubular cells initiates inflammation and leads to calcification. Many exciting new papers though not denying this hypothesis point toward a role of vascular injury-atherosclerosis – calcifying nanoparticles in pathogenesis of Randall's plaque. Hence, renal stone disease may be a harbinger of cardiovascular pathology and vice versa.

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